Life span of a mature lymphocyte

B lymphocyte differentiation and B cell death do not allow mature B cell accumulation. This result does not support the notion that peripheral B cells accumulate in animals with decreased but constant BM B cell production.

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I wonder whether quantitative changes in the parameters of B cell dynamics may lead to qualitative changes in repertoire selection.


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B lymphocyte life span, rate of division and differentiation are regulated by total cell number

Thus, peripheral survival is also dependent on the rate of BM output and the ability of newly generated cells todisplace peripheral lymphocytes. The number of LN-derived B cells recovered in the hosts without or with reduced BM B cell production groups 1—5 is greater compared with the controls group 6. Role of transcription factors.
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